Article
Identification of genetic loci associated with different responses to high-fat diet-induced obesity in C57BL/6N and C57BL/6J substrains.
Physiological genomics - 1 Jun 2014
Heiker John T, Kunath Anne, Kosacka Joanna, Flehmig Gesine, Knigge Anja, Kern Matthias, Stumvoll Michael, Kovacs Peter, Blüher Matthias, Klöting Nora
Abstract excerpt
We have recently demonstrated that C57BL/6NTac and C57BL/6JRj substrains are significantly different in their response to high-fat diet-induced obesity (DIO). The C57BL/6JRj substrain seems to be protected from DIO and genetic differences between C57BL/6J and C57BL/6N substrains at 11 single nucleotide polymorphism (SNP) loci have been identified. To define genetic variants as well as differences in parameters of...
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