Identification of mutations through dominant screening for obesity using C57BL/6 substrains.

doi:10.1038/srep32453

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Article

Identification of mutations through dominant screening for obesity using C57BL/6 substrains.

Scientific reports - 2 Sept 2016

Hossain Mohammad Sarowar, Asano Fuyuki, Fujiyama Tomoyuki, Miyoshi Chika, Sato Makito, Ikkyu Aya, Kanno Satomi, Hotta Noriko, Kakizaki Miyo, Honda Takato, Kim Staci J, Komiya Haruna, Miura Ikuo, Suzuki Tomohiro, Kobayashi Kimio, Kaneda Hideki, Kumar Vivek, Takahashi Joseph S, Wakana Shigeharu, Funato Hiromasa, Yanagisawa Masashi

Abstract excerpt

The discovery of leptin substantiated the usefulness of a forward genetic approach in elucidating the molecular network regulating energy metabolism. However, no successful dominant screening for obesity has been reported, which may be due to the influence of quantitative trait loci between the screening and counter strains and the low fertility of obese mice. Here, we performed a dominant screening for obesity...

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PMID: 27585985
DOI: 10.1038/srep32453
PMCID: PMC5009433

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