Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary.

doi:10.1111/jog.12324

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Article

Mutational analysis of FOXL2 p.C134W and expression of bone morphogenetic protein 2 in Japanese patients with granulosa cell tumor of ovary.

The journal of obstetrics and gynaecology research - 1 May 2014

Oseto Kumiko, Suzumori Nobuhiro, Nishikawa Ryutaro, Nishikawa Hiroshi, Arakawa Atsushi, Ozaki Yasuhiko, Asai Hidekazu, Kawai Michiyasu, Mizuno Kimio, Takahashi Satoru, Shirai Tomoyuki, Yamada-Namikawa Chisato, Nakanishi Makoto, Kajiyama Hiroaki, Kikkawa Fumitaka, Sugiura-Ogasawara Mayumi

Abstract excerpt

AIM: To assess whether FOXL2 p.C134W mutation may play a role in the development of human ovarian tumors in the Japanese, we investigated the FOXL2 codon 134 mutation and protein expression of inhibin-α, bone morphogenetic protein 2 (BMP2) and follistatin (FST) in Japanese patients with granulosa cell tumor (GCT) of the ovary and other ovarian tumors. METHODS: We analyzed 114 tumor tissues from ovarian tumors,...

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Identifiers

PMID: 24689977
DOI: 10.1111/jog.12324

Genes

FOXL2
BMP2
FST

Variants

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