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Article

Mutational analysis of <i>FOXL2</i> codon 134 in granulosa cell tumour of ovary and other human cancers

19 Jan 2010

Abstract excerpt

A missense somatic mutation in the FOXL2 gene affecting codon 134 has recently been reported in granulosa cell tumour (GCT) and thecoma of the ovary. Such a recurrent nature of the mutation strongly suggests that the FOXL2 mutation may play an important role in the development of ovarian sex cord-stromal tumours. The aim of this study was to characterize the FOXL2 mutation in human tumour tissues. We analysed...

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PMID: 20198651
DOI: 10.1002/path.2688

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Mutational analysis of <i>FOXL2</i> codon 134 in granulosa cell tumour of ovary and other human cancersPMID 20198651Read ↗

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A current perspective on the pathological assessment of <i><scp>FOXL</scp>2</i> in adult‐type granulosa cell tumours of the ovarySemantic proximity Read ↗

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Adult-Type Granulosa Cell Tumors and FOXL2 MutationSemantic proximity Read ↗

The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour.Semantic proximity Read ↗

Adult ovarian granulosa cell tumor transcriptomics: prevalence of FOXL2 target genes misregulation gives insights into the pathogenic mechanism of the p.Cys134Trp somatic mutation.Semantic proximity Read ↗

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