Article
HER2 and TOP2A amplification in a hospital-based cohort of breast cancer patients: associations with patient and tumor characteristics.
Breast cancer research and treatment - 1 May 2014
Fasching Peter A, Weihbrecht Sebastian, Haeberle Lothar, Gasparyan Armen, Villalobos Ivonne E, Ma Yanling, Ekici Arif B, Wachter David L, Hartmann Arndt, Beckmann Matthias W, Slamon Dennis J, Press Michael F
Abstract excerpt
Gene amplification is an important factor for altered gene expression in breast cancers. TOP2A-amplification often occurs concomitantly with HER2 amplification, and it has been suggested to be predictive for the response to anthracycline chemotherapy. This study assessed the correlation between HER2 status and TOP2A co-amplification, the possible association of TOP2A single-nucleotide polymorphisms with the...
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