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Article

Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Mar 2011

Press Michael F, Sauter Guido, Buyse Marc, Bernstein Leslie, Guzman Roberta, Santiago Angela, Villalobos Ivonne E, Eiermann Wolfgang, Pienkowski Tadeusz, Martin Miguel, Robert Nicholas, Crown John, Bee Valerie, Taupin Henry, Flom Kerry J, Tabah-Fisch Isabelle, Pauletti Giovanni, Lindsay Mary-Ann, Riva Alessandro, Slamon Dennis J

Abstract excerpt

PURPOSE: Approximately 35% of HER2-amplified breast cancers have coamplification of the topoisomerase II-alpha (TOP2A) gene encoding an enzyme that is a major target of anthracyclines. This study was designed to evaluate whether TOP2A gene alterations may predict incremental responsiveness to ant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type II

Share to Gene Amplification

Share to Genes, erbB-2

Share to Poly-ADP-Ribose Binding Proteins

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Source

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Identifiers

PMID: 21189395
DOI: 10.1200/JCO.2009.27.5644
PMCID: PMC3068060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21189395-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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