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Article

SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker.

Oncotarget - 15 Mar 2014

Kolukula Vamsi K, Sahu Geetaram, Wellstein Anton, Rodriguez Olga C, Preet Anju, Iacobazzi Vito, D'Orazi Gabriella, Albanese Chris, Palmieri Ferdinando, Avantaggiati Maria Laura

Abstract excerpt

Mutations of the p53 gene hallmark many human cancers. Several p53 mutant proteins acquire the capability to promote cancer progression and metastasis, a phenomenon defined as Gain of Oncogenic Function (GOF). The downstream targets by which GOF p53 mutants perturb cellular programs relevant to oncogenesis are only partially known. We have previously demonstrated that SLC25A1 (CIC) promotes tumorigenesis, while...

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Identifiers

PMID: 24681808
DOI: 10.18632/oncotarget.1831
PMCID: PMC4012738

Genes

CIC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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