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Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery

30 Dec 2014

Abstract excerpt

Proper functioning of cilia, hair-like structures responsible for sensation and locomotion, requires nephrocystin-5 (NPHP5) and a multi-subunit complex called the Bardet-Biedl syndrome (BBS)ome, but their precise relationship is not understood. The BBSome is involved in the trafficking of membrane cargos to cilia. While it is known that a loss of any single subunit prevents ciliary trafficking of the BBSome and...

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PMID: 25552655
DOI: 10.1093/hmg/ddu738

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Related research

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Research trail→

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Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo deliveryPMID 25552655Read ↗

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The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architectureSemantic proximity Read ↗

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Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy.Semantic proximity Read ↗

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