Article

Soluble mannose receptor induces pro-inflammatory macrophage activation and metaflammation

2020-09-30

Abstract excerpt

Pro-inflammatory activation of macrophages in metabolic tissues is critically important in induction of obesity-induced metaflammation. Here, we demonstrate that the soluble mannose receptor (sMR) plays a direct, functional role in both macrophage activation and metaflammation. We show that sMR binds CD45 on macrophages and inhibits its phosphatase activity, leading to a Src/Akt/NF-κB-mediated cellular reprogrammi...

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Literature Corpus work: c6342b2d-c0a8-5b6d-be06-0a3d6c1d0222
DOI: 10.1101/2020.09.29.315598

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