Article
Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to low doses of heavy-ion radiation.
Mutation research - 1 Jul 2011
Varès Guillaume, Wang Bing, Tanaka Kaoru, Kakimoto Ayana, Eguchi-Kasai Kyomi, Nenoi Mitsuru
Abstract excerpt
Adaptive response (AR) and bystander effect are two important phenomena involved in biological responses to low doses of ionizing radiation (IR). Furthermore, there is a strong interest in better understanding the biological effects of high-LET radiation. We previously demonstrated the ability of low doses of X-rays to induce an AR to challenging heavy-ion radiation [8]. In this study, we assessed in vitro the...
Topics
- Adaptation, Biological
- Cell Line
- DNA Repair
- Heavy Ions
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Linear Energy Transfer
- Lymphocytes
- Mutation
- Neon
- Radiation Dosage