Article
Individual differences in chromosomal aberrations after in vitro irradiation of cells from healthy individuals, cancer and cancer susceptibility syndrome patients.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Dec 2006
Distel Luitpold V R, Neubauer Susann, Keller Ulrike, Sprung Carl N, Sauer Rolf, Grabenbauer Gerhard G
Abstract excerpt
BACKGROUND: Radiosensitivity of normal tissue is a crucial factor of radiotherapy (RT)-related side effects. Here, we report the analysis of spontaneous and in vitro irradiation-induced chromosomal aberrations in 256,679 metaphases from 222 different individuals using three-color fluorescence in situ hybridization as a measure of radiosensitivity. MATERIALS AND METHODS: Samples were categorized into the following...
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