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Article

Incomplete penetrance of NRXN1 deletions in families with schizophrenia.

Schizophrenia research - 1 May 2014

Todarello Giovanna, Feng Ningping, Kolachana Bhaskar S, Li Chao, Vakkalanka Radhakrishna, Bertolino Alessandro, Weinberger Daniel R, Straub Richard E

Abstract excerpt

Neurexin 1 (NRXN1) is a presynaptic neuronal adhesion molecule that interacts with postsynaptic neuroligins in both glutamatergic and GABAergic synapses and is important in synaptic formation and function. NRXN1 deletions increase the risk of schizophrenia, so our aims were to explore this in our family sample, to distinguish de novo from inherited mutations, to examine transmission to affected and unaffected...

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Source

Identifiers

PMID: 24680031
DOI: 10.1016/j.schres.2014.02.023

Genes

NRXN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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