Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The HIV Nef protein modulates cellular and exosomal miRNA profiles in human monocytic cells

1 Jan 2014

Abstract excerpt

INTRODUCTION: The HIV Nef protein is a multifunctional virulence factor that perturbs intracellular membranes and signalling and is secreted into exosomes. While Nef-containing exosomes have a distinct proteomic profile, no comprehensive analysis of their miRNA cargo has been carried out. Since Nef functions as a viral suppressor of RNA interference and disturbs the distribution of RNA-induced silencing complex...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular vesicles in disease
Share to HIV Research and Treatment
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24678387
DOI: 10.3402/jev.v3.23129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The HIV Nef protein modulates cellular and exosomal miRNA profiles in human monocytic cellsPMID 24678387Read ↗

Exosomes from Nef expressing monocytic cells restrict HIV-1 replication in infected cells through the assembly of stress granulesSemantic proximity Read ↗

HIV Type 1 Nef Is Released from Infected Cells in CD45 <sup>+</sup> Microvesicles and Is Present in the Plasma of HIV-Infected IndividualsSemantic proximity Read ↗

HIV-1 Nef in macrophage-mediated disease pathogenesis.Semantic proximity Read ↗

The HIV-1 Nef protein binds argonaute-2 and functions as a viral suppressor of RNA interference.Semantic proximity Read ↗

Proteomic profiling of SupT1 cells reveal modulation of host proteins by HIV-1 Nef variants.Semantic proximity Read ↗

Exosomes in Human Immunodeficiency Virus Type I Pathogenesis: Threat or Opportunity?Semantic proximity Read ↗

Role of long noncoding RNA in regulating HIV infection—a comprehensive reviewSemantic proximity Read ↗

Molecular and mechanistic analysis of HIV NefSemantic proximity Read ↗

Human semen contains exosomes with potent anti-HIV-1 activitySemantic proximity Read ↗

HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements.Semantic proximity Read ↗

How HIV Nef Proteins Hijack Membrane Traffic To Promote InfectionSemantic proximity Read ↗

Characterization of the Nef protein in HIV1-infected CEM cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.