A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis.

doi:10.1007/s00406-011-0233-3

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Article

A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis.

European archives of psychiatry and clinical neuroscience - 1 Mar 2012

Lennertz Leonhard, Wagner Michael, Wölwer Wolfgang, Schuhmacher Anna, Frommann Ingo, Berning Julia, Schulze-Rauschenbach Svenja, Landsberg Martin W, Steinbrecher Anja, Alexander Michael, Franke Petra E, Pukrop Ralf, Ruhrmann Stephan, Bechdolf Andreas, Gaebel Wolfgang, Klosterkötter Joachim, Häfner Heinz, Maier Wolfgang, Mössner Rainald

Abstract excerpt

Mutations in postsynaptic scaffolding genes contribute to autism, thus suggesting a role in pathological processes in neurodevelopment. Recently, two de novo mutations in SHANK3 were described in schizophrenia patients. In most cases, abnormal SHANK3 genotype was also accompanied by cognitive disruptions. The present study queries whether common SHANK variants may also contribute to neuropsychological...

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PMID: 21901269
DOI: 10.1007/s00406-011-0233-3

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