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Article

Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling.

Blood - 22 May 2014

Taskesen Erdogan, Havermans Marije, van Lom Kirsten, Sanders Mathijs A, van Norden Yvette, Bindels Eric, Hoogenboezem Remco, Reinders Marcel J T, Figueroa Maria E, Valk Peter J M, Löwenberg Bob, Melnick Ari, Delwel Ruud

Abstract excerpt

Mutations in splice factor (SF) genes occur more frequently in myelodysplastic syndromes (MDS) than in acute myeloid leukemias (AML). We sequenced complementary DNA from bone marrow of 47 refractory anemia with excess blasts (RAEB) patients, 29 AML cases with low marrow blast cell count, and 325 other AML patients and determined the presence of SF-hotspot mutations in SF3B1, U2AF35, and SRSF2. SF mutations were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24668493
DOI: 10.1182/blood-2013-07-512855

Genes

KRAS
NRAS
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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