Article
Dual effect of a polymorphism in the macrophage migration inhibitory factor gene is associated with new-onset Graves disease in a Taiwanese Chinese population.
PloS one - 1 Jan 2014
Liu Yu-Huei, Chen Ching-Chu, Yang Chen-Ming, Chen Yi-Ju, Tsai Fuu-Jen
Abstract excerpt
Graves disease (GD) is an autoimmune disease. Macrophage migration inhibitory factor (MIF) is a potent cytokine that plays an important role in the regulation of immune responses. Two polymorphisms in the promoter region of MIF, rs5844572 and rs755622, are known to affect MIF expression. The purpose of this study was to investigate the relationship between polymorphisms in the MIF gene promoter and the severity...
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