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JMJD6 K375 acetylation restrains lung cancer progression by enhancing METTL14/m6A/SLC3A2 axis mediated cell ferroptosis

26 Feb 2025

Abstract excerpt

BACKGROUND: The Jumonji domain-containing protein 6 (JMJD6), a histone arginine demethylase, is known to have a multifaceted and significant role on cancer progression. However, the specific function and mechanism of JMJD6 in non-small cell lung cancer (NSCLC) have yet to be fully elucidated. METHODS: The elevated expression of JMJD6 in lung cancer tissues was confirmed through a combination of bioinformatics and...

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PMID: 40011892
DOI: 10.1186/s12967-025-06241-8

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