Article
Computational and Mass Spectrometry-Based Approach Identify Deleterious Non-Synonymous Single Nucleotide Polymorphisms (nsSNPs) in JMJD6.
Molecules (Basel, Switzerland) - 31 Jul 2021
Gong Tianqi, Yang Lujie, Shen Fenglin, Chen Hao, Pan Ziyue, Zhang Quanqing, Jiang Yan, Zhong Fan, Yang Pengyuan, Zhang Yang
Abstract excerpt
The jumonji domain-containing protein 6 (JMJD6) gene catalyzes the arginine demethylation and lysine hydroxylation of histone and a growing list of its known substrate molecules, including p53 and U2AF65, suggesting a possible role in mRNA splicing and transcription in cancer progression. Mass spectrometry-based technology offers the opportunity to detect SNP variants accurately and effectively. In our study, we...
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