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Article

MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression.

Cell death & disease - 14 Nov 2024

Liu Jie, Wei Xujin, Xie Yixuan, Yan Yuxiang, Xue Sihui, Wang Xiangyu, Chen Han, Pan Qilong, Yan Sisi, Zheng Xiaoling, Huang Qingling

Abstract excerpt

MDM4 is one of the major regulators of p53. The biological effect of MDM4 on tumor is controversial, its role and molecular mechanism in colon cancer progression and prognosis are still unclear. In this study, we identify that MDM4 is significantly overexpressed in human colon cancer and high MDM4 expression was associated with poor prognosis of colon cancer with mutant p53. MDM4 inhibits the ubiquitination of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39543140
DOI: 10.1038/s41419-024-07227-y
PMCID: PMC11564821

Genes

MDM4
GPX4
TRIM21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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MDM4 inhibits ferroptosis in p53 mutant colon cancer via regulating TRIM21/GPX4 expression.PMID 39543140Read ↗

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