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Article

Accurate and economical detection of ALK positive lung adenocarcinoma with semiquantitative immunohistochemical screening.

PloS one - 1 Jan 2014

Zhou Jianya, Zhao Jing, Sun Ke, Wang Bo, Wang Lijun, Chen Xi, Zheng Jing, You Qihan, Wang Xiaoling, Ding Wei, Zhou Jianying

Abstract excerpt

Right detection of anaplastic lymphoma kinase (ALK) gene rearrangement is pivotal to selection of patients with lung adenocarcinoma for ALK-targeted therapy. We explored the potential of combination of immunohistochemistry (IHC) screening and fluorescence in situ hybridization (FISH) as an affordable practice. We analyzed 410 unselected lung adenocarcinomas by ALK IHC (D5F3 clone) and FISH. Some equivocal cases...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24667320
DOI: 10.1371/journal.pone.0092828
PMCID: PMC3965450

Genes

ALK
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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