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Article

Immunohistochemical screening for anaplastic lymphoma kinase (ALK) rearrangement in advanced non-small cell lung cancer patients.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2012

Park Heae Surng, Lee June Koo, Kim Dong-Wan, Kulig Kimary, Kim Tae Min, Lee Se-Hoon, Jeon Yoon-Kyung, Chung Doo Hyun, Heo Dae Seog

Abstract excerpt

Fluorescence in situ hybridization (FISH) is currently used to detect non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK) gene rearrangement, who are candidates for ALK inhibitor therapy. However, FISH may not be a practical method for screening for ALK-positive patients in a large population due to its cost and difficulty in interpretation. We investigated the role of...

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Source

Identifiers

PMID: 22465695
DOI: 10.1016/j.lungcan.2012.03.004

Genes

ALK
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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