Modeling studies on the structural determinants for the DAG/phorbol ester binding to C1 domain.

Abstract excerpt

C1 domains are small zinc-binding structural units of approximately 50 amino acids, originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to the DAG/phorbol ester are termed as typical, and those that do not respond to DAG/phorbol ester are termed as atypical. To design molecules targeting a specific C1 domain for regulating a specific disease state,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diglycerides
• Share to Molecular Docking Simulation
• Share to Molecular Dynamics Simulation