Article
Transcriptome analysis identifies Bacillus anthracis genes that respond to CO2 through an AtxA-dependent mechanism.
BMC genomics - 25 Mar 2014
McKenzie Andrew T, Pomerantsev Andrei P, Sastalla Inka, Martens Craig, Ricklefs Stacy M, Virtaneva Kimmo, Anzick Sarah, Porcella Stephen F, Leppla Stephen H
Abstract excerpt
BACKGROUND: Upon infection of a mammalian host, Bacillus anthracis responds to host cues, and particularly to elevated temperature (37°C) and bicarbonate/CO2 concentrations, with increased expression of virulence factors that include the anthrax toxins and extracellular capsular layer. This response requires the presence of the pXO1 virulence plasmid-encoded pleiotropic regulator AtxA. To better understand the...
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