Article

Paradoxical Aortic Stiffening and Subsequent Cardiac Dysfunction in Hutchinson-Gilford Progeria Syndrome

2019-10-02

Abstract excerpt

<h4>SUMMARY</h4> Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare disorder with devastating sequelae resulting in early death, presently believed to stem primarily from heart failure secondary to central arterial stiffening. We analyze novel longitudinal cardiovascular data from a mouse model of HGPS ( Lmna G609G/G609G ) using allometric scaling and advanced computational modelling and show that a la...

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Literature Corpus work: 8aea1917-91a8-5269-8081-dee7bcb6b7a7
DOI: 10.1101/790477

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