Article
Genetic modification of the relationship between phosphorylated tau and neurodegeneration.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2014
Hohman Timothy J, Koran Mary Ellen I, Thornton-Wells Tricia A
Abstract excerpt
BACKGROUND: A subset of individuals present at autopsy with the pathologic features of Alzheimer's disease having never manifest the clinical symptoms. We sought to identify genetic factors that modify the relationship between phosphorylated tau (PTau) and dilation of the lateral inferior ventricles. METHODS: We used data from 700 subjects enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). A...
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