Article
Lack of association between genetic variability and multiple pain-related outcomes in a large cohort of patients with advanced cancer: the European Pharmacogenetic Opioid Study (EPOS).
BMJ supportive & palliative care - 1 Dec 2012
Fladvad Torill, Fayers Peter, Skorpen Frank, Kaasa Stein, Klepstad Pål
Abstract excerpt
OBJECTIVE: This study examined whether the choice of pain-related outcome to represent opioid efficacy influenced findings in a genetic association study. Data from the European Pharmacogenetic Opioid Study, which used opioid dose as the outcome, were analysed in respect of six alternative outcomes: average pain intensity, pain right now, worst pain intensity, pain at its least, pain relief and pain interference....
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