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Article

Prochlorperazine enhances radiosensitivity of non-small cell lung carcinoma by stabilizing GDP-bound mutant KRAS conformation.

Free radical biology & medicine - 1 Dec 2021

Sad Kirti, Parashar Palak, Tripathi Pragya, Hungyo Hungharla, Sistla Ramesh, Soni Ravi, Tandon Vibha

Abstract excerpt

Lung cancer is considered as leading cancer with the highest mortality. The KRAS-oncogenic mutations are dominant in lung carcinoma leading to poor prognosis and radioresistance, which is a major impediment to radiotherapy. Thus, KRAS mutant inhibitors that synergistically sensitize tumours to radiation are urgently needed. In pursuance of the search for a novel radiosensitizer, high-throughput screening of...

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Identifiers

PMID: 34742922
DOI: 10.1016/j.freeradbiomed.2021.11.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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