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Article

Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation.

Gastroenterology - 1 Jul 2010

Garuti Cinzia, Tian Yinghua, Montosi Giuliana, Sabelli Manuela, Corradini Elena, Graf Rolf, Ventura Paolo, Vegetti Alberto, Clavien Pierre-Alain, Pietrangelo Antonello

Abstract excerpt

BACKGROUND & AIMS: Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the s...

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Share to Antimicrobial Cationic Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20338170
DOI: 10.1053/j.gastro.2010.03.043

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20338170-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation.PMID 20338170Read ↗

Hfe acts in hepatocytes to prevent hemochromatosis.Semantic proximity Read ↗

Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse.Semantic proximity Read ↗

Mouse models of hereditary hemochromatosis do not develop early liver fibrosis in response to a high fat dietSemantic proximity Read ↗

Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype.Semantic proximity Read ↗

Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.Semantic proximity Read ↗

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.Semantic proximity Read ↗

Survival after liver transplantation in patients with hepatic iron overload: the national hemochromatosis transplant registry.Semantic proximity Read ↗

HFE gene knockout produces mouse model of hereditary hemochromatosisSemantic proximity Read ↗

Mechanisms of Iron Accumulation in Hereditary HemochromatosisSemantic proximity Read ↗

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.Semantic proximity Read ↗

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.Semantic proximity Read ↗

A high-fat diet modulates iron metabolism but does not promote liver fibrosis in hemochromatotic Hjv⁻/⁻ mice.Semantic proximity Read ↗

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