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Article

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

2 Mar 2011

Abstract excerpt

Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release. Here we show that the liver-specific microRNA miR-122 is important for regulating Hamp mRNA expression and tissue iron levels. Efficient and specific depletion of miR-122 by injection of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21364282
DOI: 10.1172/jci44883

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