Article
Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.
The Journal of biological chemistry - 2 May 2014
Rappe Ulrike, Schlechter Tanja, Aschoff Moritz, Hotz-Wagenblatt Agnes, Hofmann Ilse
Abstract excerpt
The armadillo repeat protein ARVCF is a component of adherens junctions. Similar to related proteins, such as p120-catenin and β-catenin, with known signaling functions, localization studies indicate a cytoplasmic and a nuclear pool of ARVCF. We find that ARVCF interacts with different proteins involved in mRNA-processing: the splicing factor SRSF1 (SF2/ASF), the RNA helicase p68 (DDX5), and the heterogeneous...
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