Article
The Rpe65 rd12 allele exerts a semidominant negative effect on vision in mice.
Investigative ophthalmology & visual science - 17 Apr 2014
Wright Charles B, Chrenek Micah A, Feng Wei, Getz Shannon E, Duncan Todd, Pardue Machelle T, Feng Yue, Redmond T Michael, Boatright Jeffrey H, Nickerson John M
Abstract excerpt
PURPOSE: The rd12 mouse was reported as a recessively inherited Rpe65 mutation. We asked if the rd12 mutation resides in Rpe65 and how the mutation manifests itself. METHODS: A complementation test was performed by mating Rpe65(KO) (KO/KO) and rd12 mice together to determine if the rd12 mutation is in the Rpe65 gene. Visual function of wild-type (+/+), KO/+, rd12/+, KO/KO, rd12/rd12, and KO/rd12 mice was measured...
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