Article
Complementation test of Rpe65 knockout and tvrm148.
Investigative ophthalmology & visual science - 30 Jul 2013
Wright Charles B, Chrenek Micah A, Foster Stephanie L, Duncan Todd, Redmond T Michael, Pardue Machelle T, Boatright Jeffrey H, Nickerson John M
Abstract excerpt
PURPOSE: A mouse mutation, tvrm148, was previously reported as resulting in retinal degeneration. Tvrm148 and Rpe65 map between markers D3Mit147 and D3Mit19 on a genetic map, but the physical map places RPE65 outside the markers. We asked if Rpe65 or perhaps another nearby gene is mutated and if the mutant reduced 11-cis-retinal levels. We studied the impact of the tvrm148 mutation on visual function, morphology,...
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