Article
Heterogeneous stock rat: a unique animal model for mapping genes influencing bone fragility.
Bone - 1 May 2011
Alam Imranul, Koller Daniel L, Sun Qiwei, Roeder Ryan K, Cañete Toni, Blázquez Gloria, López-Aumatell Regina, Martínez-Membrives Esther, Vicens-Costa Elia, Mont Carme, Díaz Sira, Tobeña Adolf, Fernández-Teruel Alberto, Whitley Adam, Strid Pernilla, Diez Margarita, Johannesson Martina, Flint Jonathan, Econs Michael J, Turner Charles H, Foroud Tatiana
Abstract excerpt
Previously, we demonstrated that skeletal mass, structure and biomechanical properties vary considerably among 11 different inbred rat strains. Subsequently, we performed quantitative trait loci (QTL) analysis in four inbred rat strains (F344, LEW, COP and DA) for different bone phenotypes and identified several candidate genes influencing various bone traits. The standard approach to narrowing QTL intervals down...
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