Article
Identification of genes influencing skeletal phenotypes in congenic P/NP rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2010
Alam Imranul, Carr Lucinda G, Liang Tiebing, Liu Yunlong, Edenberg Howard J, Econs Michael J, Turner Charles H
Abstract excerpt
We previously showed that alcohol-preferring (P) rats have higher bone density than alcohol-nonpreferring (NP) rats. Genetic mapping in P and NP rats identified a major quantitative trait locus (QTL) between 4q22 and 4q34 for alcohol preference. At the same location, several QTLs linked to bone density and structure were detected in Fischer 344 (F344) and Lewis (LEW) rats, suggesting that bone mass and strength...
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