Article
Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences.
Virchows Archiv : an international journal of pathology - 1 Jan 2001
Chiaravalli A M, Furlan D, Facco C, Tibiletti M G, Dionigi A, Casati B, Albarello L, Riva C, Capella C
Abstract excerpt
Alterations of DNA mismatch repair (MMR) genes are involved in carcinogenesis of sporadic and inherited human cancers characterised by instability of DNA microsatellite sequences (MSI). MSI tumours are usually identified using molecular analysis. In the present investigation, hMLH1 and hMSH2 immunohistochemistry was tested in order to evaluate the utility of this method in predicting MMR deficiency. Colorectal...
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