Article
Study of Toll-like Receptor 3 Gene Polymorphism as a Novel Risk Factor for HCV-related Hepatocellular Carcinoma in Egypt.
Current cancer drug targets - 1 Jan 2020
El-Sharawy Shimaa, Negm Osama El-Sayed, Abd-Elsalam Sherief, El-Sorogy Hesham Ahmed, Shehata Mona Ahmed Helmy
Abstract excerpt
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is a highly aggressive cancer with few treatment options. Toll-like receptor 3 (TLR3) plays a key role in innate immunity and may affect the development of cancers. This study aimed to investigate the association between TLR3 gene polymorphism and HCV-related hepatocellular carcinoma in Egypt. METHODS: This work was conducted on 70 individuals; fifty HCV...
Topics
- Adult
- Aged
- Biomarkers, Tumor
- Carcinoma, Hepatocellular
- Case-Control Studies
- Egypt
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Genotype
- Hepacivirus
- Hepatitis C
- Humans
- Liver Neoplasms