Article
Sulforaphane protects from T cell-mediated autoimmune disease by inhibition of IL-23 and IL-12 in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2014
Geisel Julia, Brück Jürgen, Glocova Ivana, Dengler Katja, Sinnberg Tobias, Rothfuss Oliver, Walter Michael, Schulze-Osthoff Klaus, Röcken Martin, Ghoreschi Kamran
Abstract excerpt
Sulforaphane (SFN), an isothiocyanate, is part of an important group of naturally occurring small molecules with anti-inflammatory properties. The published reports are best conceivable with an inhibition of T cell function, but the mode of action remains unknown. We therefore analyzed the effect of SFN on T cell-mediated autoimmune disease. Feeding mice with SFN protected from severe experimental autoimmune...
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