Article
Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis.
Clinical immunology (Orlando, Fla.) - 1 Mar 2012
Zhu Bing, Trikudanathan Subbulaxmi, Zozulya Alla L, Sandoval-Garcia Carolina, Kennedy Jennifer K, Atochina Olga, Norberg Thomas, Castagner Bastien, Seeberger Peter, Fabry Zsuzsa, Harn Donald, Khoury Samia J, Guleria Indira
Abstract excerpt
Parasitic infections frequently lead to immune deviation or suppression. However, the application of specific parasitic molecules in regulating autoimmune responses remains to be explored. Here we report on the immune modulatory function of Lacto-N-fucopentaose III (LNFPIII), a schistosome glycan, in an animal model for multiple sclerosis. We found that LNFPIII treatment significantly reduced the severity of...
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