Article
Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis.
Neurogenetics - 1 May 2014
Lill Christina M, Schilling Marcel, Ansaloni Sara, Schröder Julia, Jaedicke Marian, Luessi Felix, Schjeide Brit-Maren M, Mashychev Andriy, Graetz Christiane, Akkad Denis A, Gerdes Lisa-Ann, Kroner Antje, Blaschke Paul, Hoffjan Sabine, Winkelmann Alexander, Dörner Thomas, Rieckmann Peter, Steinhagen-Thiessen Elisabeth, Lindenberger Ulman, Chan Andrew, Hartung Hans-Peter, Aktas Orhan, Lohse Peter, Buttmann Mathias, Kümpfel Tania, Kubisch Christian, Zettl Uwe K, Epplen Joerg T, Zipp Frauke, Bertram Lars
Abstract excerpt
Recent large-scale association studies have identified over 100 MS risk loci. One of these MS risk variants is single-nucleotide polymorphism (SNP) rs17066096, located ~14 kb downstream of IL22RA2. IL22RA2 represents a compelling MS candidate gene due to the role of IL-22 in autoimmunity; however, rs17066096 does not map into any known functional element. We assessed whether rs17066096 or a nearby proxy SNP may...
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