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Article

Long term expansion of bone marrow-derived hMSCs on novel synthetic microcarriers in xeno-free, defined conditions.

PloS one - 1 Jan 2014

Hervy Martial, Weber Jennifer L, Pecheul Marylene, Dolley-Sonneville Paula, Henry David, Zhou Yue, Melkoumian Zara

Abstract excerpt

Human mesenchymal stem cells (hMSCs) present an attractive target for cell therapy given their wide availability, immunomodulatory properties, and multipotent nature for differentiation into chondrocytes, osteocytes, and adipocytes. With the progression of hMSC clinical studies, there is an increasing demand for development of technologies that enable efficient cell scale-up into clinically relevant quantities....

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PMID: 24638103
DOI: 10.1371/journal.pone.0092120
PMCID: PMC3956887

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