Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rogdi Defines GABAergic Control of a Wake-promoting Dopaminergic Pathway to Sustain Sleep in Drosophila.

Scientific reports - 12 Sept 2017

Kim Minjong, Jang Donghoon, Yoo Eunseok, Oh Yangkyun, Sonn Jun Young, Lee Jongbin, Ki Yoonhee, Son Hyo Jin, Hwang Onyou, Lee Changwook, Lim Chunghun, Choe Joonho

Abstract excerpt

Kohlschutter-Tönz syndrome (KTS) is a rare genetic disorder with neurological dysfunctions including seizure and intellectual impairment. Mutations at the Rogdi locus have been linked to development of KTS, yet the underlying mechanisms remain elusive. Here we demonstrate that a Drosophila homolog of Rogdi acts as a novel sleep-promoting factor by supporting a specific subset of gamma-aminobutyric acid (GABA)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to Dopamine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GABAergic Neurons

Share to gamma-Aminobutyric Acid

Share to Loss of Function Mutation

Share to Receptors, GABA

Share to Wakefulness

Source

Open in PubMed Open full text

Identifiers

PMID: 28900300
DOI: 10.1038/s41598-017-11941-3
PMCID: PMC5595912

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rogdi Defines GABAergic Control of a Wake-promoting Dopaminergic Pathway to Sustain Sleep in Drosophila.PMID 28900300Read ↗

Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy.Semantic proximity Read ↗

Identifying sleep regulatory genes using a Drosophila model of insomnia.Semantic proximity Read ↗

DBT affects sleep in both circadian and non-circadian neurons.Semantic proximity Read ↗

Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's diseaseSemantic proximity Read ↗

Neuronal machinery of sleep homeostasis in Drosophila.Semantic proximity Read ↗

The Drosophila Circadian Clock Gates Sleep through Time-of-Day Dependent Modulation of Sleep-Promoting Neurons.Semantic proximity Read ↗

Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila.Semantic proximity Read ↗

<i>Drosophila</i> Modeling of Insomnia-Associated Genes Reveals Diverse Underlying Sleep PhenotypesSemantic proximity Read ↗

The Kohlschütter-Tönz syndrome associated gene Rogdi encodes a novel presynaptic protein.Semantic proximity Read ↗

New developments in sleep research: molecular genetics, gene expression, and systems neurobiology.Semantic proximity Read ↗

Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.Semantic proximity Read ↗

Genetics of sleep.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.