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Article

Whole-genome sequencing of an aggressive BRAF wild-type papillary thyroid cancer identified EML4-ALK translocation as a therapeutic target.

World journal of surgery - 1 Jun 2014

Demeure Michael J, Aziz Meraj, Rosenberg Richard, Gurley Steven D, Bussey Kimberly J, Carpten John D

Abstract excerpt

BACKGROUND: Recent advances in the treatment of cancer have focused on targeting genomic aberrations with selective therapeutic agents. In radioiodine resistant aggressive papillary thyroid cancers, there remain few effective therapeutic options. A 62-year-old man who underwent multiple operations for papillary thyroid cancer and whose metastases progressed despite standard treatments provided tumor tissue....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24633422
DOI: 10.1007/s00268-014-2485-3

Genes

ALK
EML4
BRAF
NRAS
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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