Article
Serum from patients with systemic vasculitis induces alternatively activated macrophage M2c polarization.
Clinical immunology (Orlando, Fla.) - 1 Jan 2000
Ohlsson Susanne M, Linge Carl Petrus, Gullstrand Birgitta, Lood Christian, Johansson Asa, Ohlsson Sophie, Lundqvist Andrea, Bengtsson Anders A, Carlsson Fredric, Hellmark Thomas
Abstract excerpt
Anti-neutrophil cytoplasmic antibody associated vasculitides (AAV) are conditions defined by an autoimmune small vessel inflammation. Dying neutrophils are found around the inflamed vessels and the balance between infiltrating neutrophils and macrophages is important to prevent autoimmunity. Here we investigate how sera from AAV patients may regulate macrophage polarization and function. Macrophages from healthy...
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