The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.

doi:10.1016/j.febslet.2014.02.063

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Article

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties.

FEBS letters - 2 May 2014

Megarity Clare F, Gill James R E, Caraher M Clare, Stratford Ian J, Nolan Karen A, Timson David J

Abstract excerpt

There are two common forms of NRH-quinone oxidoreductase 2 (NQO2) in the human population resulting from SNP rs1143684. One has phenylalanine at position 47 (NQO2-F47) and the other leucine (NQO2-L47). Using recombinant proteins, we show that these variants have similar steady state kinetic parameters, although NQO2-L47 has a slightly lower specificity constant. NQO2-L47 is less stable towards proteolytic...

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PMID: 24631540
DOI: 10.1016/j.febslet.2014.02.063
PMCID: PMC4045209

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NQO2

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