Article
A functional polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, dysfunction, and ischemia: data from the heart and soul study.
PloS one - 20 Oct 2010
Farzaneh-Far Ramin, Desir Gary V, Na Beeya, Schiller Nelson B, Whooley Mary A
Abstract excerpt
BACKGROUND: Renalase is a soluble enzyme that metabolizes circulating catecholamines. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has recently been described. The association of this polymorphism with cardiac structure, function, and ischemia has not previously been reported. METHODS: We genotyped the rs2296545 single-nucleotide polymorphism...
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