Article
WIDE AWAKE mediates the circadian timing of sleep onset.
Neuron - 2 Apr 2014
Liu Sha, Lamaze Angelique, Liu Qili, Tabuchi Masashi, Yang Yong, Fowler Melissa, Bharadwaj Rajnish, Zhang Julia, Bedont Joseph, Blackshaw Seth, Lloyd Thomas E, Montell Craig, Sehgal Amita, Koh Kyunghee, Wu Mark N
Abstract excerpt
How the circadian clock regulates the timing of sleep is poorly understood. Here, we identify a Drosophila mutant, wide awake (wake), that exhibits a marked delay in sleep onset at dusk. Loss of WAKE in a set of arousal-promoting clock neurons, the large ventrolateral neurons (l-LNvs), impairs sleep onset. WAKE levels cycle, peaking near dusk, and the expression of WAKE in l-LNvs is Clock dependent. Strikingly,...
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