Article
Determinants beyond both complementarity and cleavage govern microR159 efficacy in Arabidopsis.
PLoS genetics - 1 Mar 2014
Li Junyan, Reichel Marlene, Millar Anthony A
Abstract excerpt
Plant microRNAs (miRNAs) are critical regulators of gene expression, however little attention has been given to the principles governing miRNA silencing efficacy. Here, we utilize the highly conserved Arabidopsis miR159-MYB33/MYB65 regulatory module to explore these principles. Firstly, we show that perfect central complementarity is not required for strong silencing. Artificial miR159 variants with two cleavage...
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