Article
Introns of plant pri-miRNAs enhance miRNA biogenesis.
EMBO reports - 1 Jul 2013
Bielewicz Dawid, Kalak Malgorzata, Kalyna Maria, Windels David, Barta Andrea, Vazquez Franck, Szweykowska-Kulinska Zofia, Jarmolowski Artur
Abstract excerpt
Plant MIR genes are independent transcription units that encode long primary miRNA precursors, which usually contain introns. For two miRNA genes, MIR163 and MIR161, we show that introns are crucial for the accumulation of proper levels of mature miRNA. Removal of the intron in both cases led to a drop-off in the level of mature miRNAs. We demonstrate that the stimulating effects of the intron mostly reside in...
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