Article
Succinate dehydrogenase deficiency is rare in pituitary adenomas.
The American journal of surgical pathology - 1 Apr 2014
Gill Anthony J, Toon Christopher W, Clarkson Adele, Sioson Loretta, Chou Angela, Winship Ingrid, Robinson Bruce G, Benn Diana E, Clifton-Bligh Roderick J, Dwight Trisha
Abstract excerpt
Germline mutations in the succinate dehydrogenase genes (SDHA, SDHB, SDHC, and SDHD) are established as causes of pheochromocytoma/paraganglioma, renal carcinoma, and gastrointestinal stromal tumor. It has recently been suggested that pituitary adenomas may also be a component of this syndrome. We sought to determine the incidence of SDH mutation in pituitary adenomas. We performed screening immunohistochemistry...
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