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Article

MDM2 SNP309 promoter polymorphism confers risk for hereditary melanoma.

Melanoma research - 1 Jun 2014

Thunell Lena K, Bivik Cecilia, Wäster Petra, Fredrikson Mats, Stjernström Annika, Synnerstad Ingrid, Rosdahl Inger, Enerbäck Charlotta

Abstract excerpt

The p53 pathway regulates stress response, and variations in p53, MDM2, and MDM4 may predispose an individual to tumor development. The aim of this study was to study the impact of genetic variation on sporadic and hereditary melanoma. We have analyzed a combination of three functionally relevant variants of the p53 pathway in 258 individuals with sporadic malignant melanomas, 50 with hereditary malignant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24625390
DOI: 10.1097/CMR.0000000000000063

Genes

MDM2
MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MDM2 SNP309 promoter polymorphism confers risk for hereditary melanoma.PMID 24625390Read ↗

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MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis.Semantic proximity Read ↗

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MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 GG genotype and tumor Breslow thickness.Semantic proximity Read ↗

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